Spinach Artichoke Grilled Cheese

Featured in: One-Dish Kitchen Cooking

This elevated grilled cheese combines fresh spinach, tender artichoke hearts, and a blend of three cheeses—mozzarella, cream cheese, and Parmesan—for a rich, creamy filling. Nestled between buttered sourdough slices, it's griddled until the bread turns golden brown and the cheese melts into every bite. Ready in just 25 minutes, this vegetarian sandwich pairs beautifully with tomato soup and offers room for customization with fresh basil or smoked paprika.

Updated on Sun, 18 Jan 2026 15:16:00 GMT
Golden-brown sourdough sandwiches stuffed with creamy spinach and artichoke filling, served hot. Pin It
Golden-brown sourdough sandwiches stuffed with creamy spinach and artichoke filling, served hot. | bowlbuffer.com

My neighbor knocked on the door one Saturday holding a jar of artichoke hearts she didn't know what to do with. I had spinach wilting in the fridge and a craving for something warm and melty. We stood in my kitchen, tossing ideas back and forth, and somehow landed on stuffing it all into a grilled cheese. The first bite was so good we made two more rounds before she even went home.

I started making this on rainy afternoons when I wanted something indulgent without leaving the house. My partner would smell the butter browning from the other room and wander in, asking what was different. It became our lazy Sunday ritual, paired with whatever was on TV and zero guilt about eating carbs for comfort.

Ingredients

  • Mozzarella cheese: This is your melt factor, the stretchy pull that makes every bite satisfying without overpowering the other flavors.
  • Cream cheese: Softened is key here so it blends smoothly and creates that luscious base that holds everything together.
  • Parmesan cheese: Adds a sharp, nutty punch that keeps the filling from tasting one note or too mild.
  • Unsalted butter: Softened butter spreads easily on the bread and crisps up into that golden, crackling crust we all want.
  • Fresh spinach: Wilts down fast and adds color and a slight earthiness that balances the richness of the cheese.
  • Artichoke hearts: Drain them well or your filling gets watery, but their tender tang is what makes this feel fancy.
  • Garlic clove: Just one small clove minced fine gives enough bite without turning your sandwich into garlic bread.
  • Sourdough bread: The slight tang and sturdy texture stand up to all that creamy filling without getting soggy.
  • Salt and black pepper: Season to taste, but don't skip them or the filling will taste flat no matter how good your cheese is.
  • Red pepper flakes: Optional, but a pinch wakes everything up and adds a gentle warmth that lingers just right.

Instructions

Product image
Season soups, salads, meats, and vegetables evenly while cooking with quick, one-handed grinding.
Check price on Amazon
Wilt the spinach:
Add your chopped spinach to a medium skillet over medium heat with just a splash of water. It only takes a minute or two to collapse into a fraction of its size, then drain off any liquid so your filling stays thick.
Mix the filling:
In a bowl, stir together the wilted spinach, chopped artichokes, cream cheese, mozzarella, Parmesan, minced garlic, salt, pepper, and red pepper flakes if using. Keep mixing until everything is evenly distributed and creamy.
Assemble the sandwiches:
Spread the spinach artichoke mixture generously onto two slices of sourdough, then top each with another slice. Press down gently so they hold together.
Butter the bread:
Spread softened butter on the outside of each sandwich, covering every edge. This is what turns the bread golden and crisp, so be thorough.
Grill until golden:
Heat a large nonstick skillet or griddle over medium heat and place your sandwiches in. Cook for 3 to 4 minutes per side, pressing gently with a spatula, until the bread is deeply golden and the cheese inside is molten.
Slice and serve:
Remove from heat, cut each sandwich in half, and serve right away while the cheese is still stretchy. The contrast between the crisp outside and creamy inside is best enjoyed hot.
Product image
Season soups, salads, meats, and vegetables evenly while cooking with quick, one-handed grinding.
Check price on Amazon
Crisp grilled cheese with vibrant green spinach and artichoke peeking from melted mozzarella. Pin It
Crisp grilled cheese with vibrant green spinach and artichoke peeking from melted mozzarella. | bowlbuffer.com

The first time I served this to friends, they thought I'd ordered it from some fancy cafe. I didn't correct them right away because watching their faces as they bit in was too satisfying. When I finally admitted I made it in ten minutes, they asked for the recipe on the spot, and I knew this one was a keeper.

Choosing Your Bread

Sourdough is my go to because the tangy flavor plays off the creamy filling and the crust gets incredibly crisp. You can swap in whole wheat or multigrain if you want something heartier, just make sure the slices are sturdy enough to hold all that cheese without falling apart. Avoid soft sandwich bread because it turns mushy under the weight of the filling and won't give you that satisfying crunch.

Pairing and Serving Ideas

This sandwich is practically begging to be dunked into a bowl of warm tomato soup, the classic combo for a reason. I also love it with a simple side salad dressed in lemon vinaigrette to cut through the richness. Sometimes I'll make a double batch of the filling and keep it in the fridge for quick lunches all week, just spreading it fresh on bread whenever the craving hits.

Customizing the Filling

You can fold in a handful of chopped fresh basil right before assembling for a bright, herby note that feels summery. A sprinkle of smoked paprika in the filling adds a subtle smokiness that makes it taste almost like it came off a grill. If you want more vegetables, finely diced roasted red peppers or sun dried tomatoes blend right in without changing the texture too much.

  • Try swapping half the mozzarella for Gruyere if you want a nuttier, more complex flavor.
  • Add a thin layer of pesto on the inside of the bread before spreading the filling for an extra punch.
  • If you like heat, a few dashes of hot sauce mixed into the filling will give it a spicy kick without overpowering the other flavors.
Product image
Make fresh ice for iced coffee, cocktails, chilling ingredients, and keeping drinks cold while cooking.
Check price on Amazon
Gourmet spinach artichoke grilled cheese, sliced to reveal a rich, cheesy, garlicky interior. Pin It
Gourmet spinach artichoke grilled cheese, sliced to reveal a rich, cheesy, garlicky interior. | bowlbuffer.com

This sandwich turned a random weekday lunch into something I actually looked forward to making. I hope it does the same for you, whether you're cooking for one or feeding a crowd.

Recipe FAQ

Can I make the spinach-artichoke filling ahead of time?

Yes, prepare the filling up to 24 hours in advance. Store it in an airtight container in the refrigerator, then assemble and cook the sandwiches when ready.

What bread works best if I don't have sourdough?

Whole wheat, multigrain, or brioche bread are excellent alternatives. Avoid thin sliced bread; choose a sturdy variety that won't compress when griddled.

How do I prevent the cheese from leaking out?

Spread the filling evenly but not to the bread edges. Leave about a quarter-inch border to contain the cheese as it melts during cooking.

Can this sandwich be frozen?

It's best enjoyed fresh. However, you can freeze the uncooked filled sandwich for up to two weeks. Thaw in the refrigerator and cook as directed.

What's the secret to crispy, golden bread?

Use medium heat and butter the outside bread slices generously. Press gently with a spatula while cooking, and allow 3–4 minutes per side for even browning.

How can I add more flavor to this sandwich?

Stir fresh basil, sun-dried tomatoes, or roasted garlic into the filling. A sprinkle of smoked paprika or red pepper flakes adds depth and a subtle kick.

Spinach Artichoke Grilled Cheese

Gourmet grilled cheese with creamy spinach and artichoke filling on toasted sourdough. A comforting vegetarian lunch or dinner.

Prep Time
15 min
Cook Time
10 min
Overall Time
25 min
Created by Anthony Perry


Skill Level Easy

Cuisine Type American

Makes 2 Portions

Dietary Information Vegetarian Friendly

What You'll Need

Dairy

01 1 cup shredded mozzarella cheese
02 1/2 cup cream cheese, softened
03 1/4 cup grated Parmesan cheese
04 2 tablespoons unsalted butter, softened

Vegetables

01 1 cup fresh spinach, chopped
02 1/2 cup canned artichoke hearts, drained and chopped
03 1 small garlic clove, minced

Bread

01 4 slices sourdough bread

Seasonings

01 1/4 teaspoon salt
02 1/8 teaspoon freshly ground black pepper
03 Pinch of red pepper flakes, optional

Directions

Step 01

Wilt the Spinach: In a medium skillet over medium heat, add spinach with a splash of water. Sauté for 1 to 2 minutes until wilted. Drain excess moisture thoroughly.

Step 02

Prepare the Filling: In a bowl, combine sautéed spinach, chopped artichoke hearts, cream cheese, mozzarella, Parmesan, minced garlic, salt, pepper, and red pepper flakes if using. Mix until well blended.

Step 03

Assemble the Sandwiches: Spread the spinach-artichoke mixture evenly onto two slices of sourdough bread. Top with the remaining bread slices to form sandwiches.

Step 04

Butter the Bread: Spread softened butter on the exterior surfaces of all bread slices.

Step 05

Cook the Sandwiches: Heat a large nonstick skillet or griddle over medium heat. Place sandwiches in the skillet and cook for 3 to 4 minutes per side, pressing gently, until bread achieves golden brown color and cheese is fully melted.

Step 06

Finish and Serve: Remove from heat, slice each sandwich in half diagonally, and serve immediately.

Equipment Needed

  • Medium skillet
  • Mixing bowl
  • Spatula
  • Nonstick skillet or griddle
  • Knife

Allergy Info

Inspect every ingredient for potential allergens and see a health expert if uncertain.
  • Contains milk from cheese and butter
  • Contains wheat from sourdough bread
  • May contain traces of soy or tree nuts depending on bread and cheese brand selection

Nutrition Details (for each serve)

These nutrition details are for reference and not intended as a substitute for professional advice.
  • Kcal: 430
  • Fats: 24 g
  • Carbohydrates: 39 g
  • Proteins: 16 g